t*d
发帖数: 1290 | 1 参考一下这个：
A major problem with validating RNA-Seq expression estimates is that there
is no clear 'gold standard' for expression estimation. Comparison of RNA-Seq
to microarrays has suggested that the former technology is more accurate
than the latter. We examined the recently published NanoString nCounter gene
expression system, but noticed many unexplainable outliers and high
variance between technical replicates (see Figure S4 of Additional file 1
and data in Additional file 2). Quantitative rev... 阅读全帖 |
|
|
i*****i
发帖数: 154 | 3 老大要找的质粒应该是叫STEMCCA
Stem Cells. 2009 Mar;27(3):543-9.
Induced pluripotent stem cell generation using a single lentiviral stem cell
cassette.
Sommer CA, Stadtfeld M, Murphy GJ, Hochedlinger K, Kotton DN, Mostoslavsky G.
Abstract
Induced pluripotent stem (iPS) cells can be generated using retroviral
vectors expressing Oct4, Klf4, Sox2, and cMyc. Most prior studies have
required multiple retroviral vectors for reprogramming, resulting in high
numbers of genomic integrations in iPS cells and limiting... 阅读全帖 |
|
|
|
v*********d
发帖数: 382 | 6 1) mTOR 控制cap-dependent translation 基本上就是因为S6Ks and 4E-BP1， 事实上
其他的几百个mTOR 调控的蛋白都忽视了， 这里面肯定还有很多水可以灌，所以才有了
今年关于Grb10 的2篇science
2) cKO mTOR 现在就2片，jcb 的muscle specific cKO 都是expected的，倒是在T-
cell 里的cko 比较出乎意料 （PMID: 19538929），所以上了immunity, 这也间接说明
了水还很深
translation？ |
|
D*a
发帖数: 6830 | 7 check this
Gerontology. 2009;55(2):205-16. Epub 2009 Feb 7.
The evolutionary theories of aging revisited--a mini-review.
Ljubuncic P, Reznick AZ.
PMID:
19202326 |
|
|
c********n
发帖数: 67 | 9 Infectious disease modeling and innate immune function in zebrafish embryos.
PMID: 21951535
c*****[email protected]
Thanks very much for your kindly help! |
|
y******a
发帖数: 590 | 10 PMID 11997071
Motor weakness and cerebellar ataxia in Sjögren syndrome--
identification of antineuronal antibody: a case report.
请发到y******[email protected]
多谢，有包子 |
|
l**********1
发帖数: 5204 | 11 HTTps://sysbio.med.harvard.edu/faculty/yin/
Nature 1月 2011 同期 一作同时两篇 from Pierce Lab at CalTech
理论RNA自我组织反应经路模拟内容的
Yin, P., Choi, H.M., Calvert, C.R., & Pierce, N.A. (2008). Programming
Biomolecular Self-Assembly Pathways. Nature, 451(7176), 318-22. PMID:
18202654. pdf.
和DNA发夹模式用于DNA自我组织反应经路模拟内容的
Yin, P., Choi, H.M., Colby, R.C., & Niles, A.P. (2008). The abstraction of a
DNA hairpin motif is used to program diverse self-assembly (and disassembly
) pathways. Nature, 451, 318-22. pdf.
他那会的老板是牛津的... 阅读全帖 |
|
Q**********r
发帖数: 214 | 12 Cold Spring Harb Protoc. 2010 Jun;2010(6)
Illumina sequencing library preparation for highly multiplexed target
capture and sequencing.
Meyer M, Kircher M
PMID 20516186
please send to a*************[email protected]
thanks a lot |
|
v****e
发帖数: 131 | 13 Postdoctoral Fellow Position
A postdoctoral fellow position is immediately available to study the
interplay between ERK3, an atypical MAP kinase, and steroid receptor co-
activators in cancer progression and metastasis. More information about our
laboratory can be found at the website: http://www.bcm.edu/mcb/index.cfm?pmid=21152.
The ideal candidate should possess a Ph.D. or M.D. degree, be self-motivated
, and have strong academic training in molecular and cellular biology.
Please send Curricul... 阅读全帖 |
|
i*e
发帖数: 352 | 14 biomark追求少比多好
J Natl Cancer Inst. 2012 Jan 18. [Epub ahead of print]
A Three-Gene Model to Robustly Identify Breast Cancer Molecular Subtypes.
Haibe-Kains B, Desmedt C, Loi S, Culhane AC, Bontempi G, Quackenbush J,
Sotiriou C.
PMID: 22262870 |
|
i*e
发帖数: 352 | 15 biomark追求少比多好
J Natl Cancer Inst. 2012 Jan 18. [Epub ahead of print]
A Three-Gene Model to Robustly Identify Breast Cancer Molecular Subtypes.
Haibe-Kains B, Desmedt C, Loi S, Culhane AC, Bontempi G, Quackenbush J,
Sotiriou C.
PMID: 22262870 |
|
g******w
发帖数: 852 | 16 No1 ------------
Genomic imprinting in Drosophila has properties of both mammalian and insect imprinting.
Anaka M, Lynn A, McGinn P, Lloyd VK.
Dev Genes Evol. 2009 Feb;219(2):59-66. Epub 2008 Nov 25.
PMID: 19031081
[PubMed - indexed for MEDLINE]
No2---------------
Nat Rev Genet. 2007 Apr;8(4):272-85.
Transposable elements and the epigenetic regulation of the genome.
Slotkin RK, Martienssen R.
Source
Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, New York 11724, USA.
... 阅读全帖 |
|
l**********1
发帖数: 5204 | 17 //www.ncbi.nlm.nih.gov/pubmed/21050804
浮黴菌門
Isosphaera屬
//hamap.expasy.org/proteomes/ISOPI.html
Species: Isosphaera pallida (strain ATCC 43644 / DSM 9630 / IS1B)
Species code: ISOPI
Taxonomy: Bacteria; Planctomycetes; Planctomycetia; Planctomycetales; Planctomycetaceae; Isosphaera
(TaxID: 575540) [NEWT/ NCBI]
Description: Isosphaera pallida strain IS1B was isolated from a hot spring in Kah-nee-tah, Oregon, USA.
It is the only budding bacterium known to glide and the only heterotrophic bacteriu... 阅读全帖 |
|
e**r
发帖数: 1144 | 18 Cell Motil Cytoskeleton. 1994;27(3):262-71.
Cellular infrared detector appears to be contained in the centrosome.
Albrecht-Buehler G.
Source
Department of Cell, Molecular, and Structural Biology, Northwestern
University Medical School, Chicago, Illinois 60611.
Abstract
Previous experiments have suggested that 3T3 cells were able to extend
pseudopodia toward latex particles up to 60 microns away from the cell body
if the particles were irradiated by an infrared beam in the range of 700-900
nm [Al... 阅读全帖 |
|
g***j
发帖数: 40861 | 19 s*****[email protected]
谢谢！
1.
Inactivation of Escherichia coli O157:H7 and Salmonella Typhimurium DT 104
on Alfalfa Seeds by Levulinic Acid and Sodium Dodecyl Sulfate
Authors: Zhao, Tong; Zhao, Ping; Doyle, Michael P.
Source: Journal of Food Protection®, Volume 73, Number 11, November
2010 , pp. 2010-2017(8)
2.
Control of Salmonella on Sprouting Mung Bean and Alfalfa Seeds by Using a
Biocontrol Preparation Based on Antagonistic Bacteria and Lytic
Bacteriophages
Authors: Ye, Jianxiong1; Kostrzyns... 阅读全帖 |
|
n******t
发帖数: 1281 | 20 FYI:
http://www.bacillusbbs.com/
Bacillus subtilis strain with inducible super-competence.
Zhang, X. Z. and Y. H. Zhang. 2011. Simple, fast and high-efficiency
transformation system for directed evolution of cellulase in Bacillus
subtilis. Microb. Biotechnol. 4:98-105. PMID: 21255377 read online
枯草杆菌感受态细胞的制备及转化
1) 将菌种接种在LB平板上37 ℃培养过夜。
2) 用接种环接一环菌苔于5mL GM I 溶液，在30 ℃慢摇床（125 r/min）振荡培养
过夜。
3) 次日取2 mL转接到18 mL GM I 中，37 ℃快摇床（250 r/min）培养3.5 h。
4) 再取10 mL上一步骤的培养液转接到90 mL GM II 中，37 ℃慢摇床培养9... 阅读全帖 |
|
v******l
发帖数: 235 | 21 Would someone please help me download this paper? I can't find in our
library. Thanks a lot! My e-mail: j********[email protected]
J Endocrinol Invest. 2005 Apr;28(4):333-9.
PMID: 15966506 [PubMed - indexed for MEDLINE]
Aminotransferase and gamma-glutamyltranspeptidase levels in obesity are
associated with insulin resistance and the metabolic syndrome.
Marchesini G, Avagnina S, Barantani EG, Ciccarone AM, Corica F, Dall'Aglio E
, Dalle Grave R, Morpurgo PS, Tomasi F, Vitacolonna E.
Source
Metabolic Un... 阅读全帖 |
|
v******l
发帖数: 235 | 22 Would someone please help me download this paper? I can't find in our
library. Thanks a lot! My e-mail: j********[email protected]
PMID: 17287148
http://www.ncbi.nlm.nih.gov/pubmed/17287148
Clin Gastroenterol Hepatol. 2007 Apr;5(4):496-501. Epub 2007 Feb 6.
Prevalence of nonalcoholic fatty liver disease in women with polycystic
ovary syndrome.
Gambarin-Gelwan M, Kinkhabwala SV, Schiano TD, Bodian C, Yeh HC, Futterweit
W.
Source
Division of Gastroenterology and Hepatology, Weill Medical College of
Corn... 阅读全帖 |
|
e****e
发帖数: 324 | 23 求各位帮忙找篇文章，发到y******[email protected]
多谢
Aminochrome as a preclinical experimental model to study degeneration of
dopaminergic neurons in Parkinson's disease.
Paris I, Cardenas S, Lozano J, Perez-Pastene C, Graumann R, Riveros A,
Caviedes P, Segura-Aguilar J.
Neurotox Res. 2007 Sep;12(2):125-34. Review.
PMID:
17967736 |
|
v******l
发帖数: 235 | 24 Would someone please help me download this paper? I can't find in our
library. Thanks a lot! My e-mail: j********[email protected]
PMID: 21197627
http://www.ncbi.nlm.nih.gov/pubmed/21197627
Genet Epidemiol. 2010 Dec 31. [Epub ahead of print]
Predicting multiallelic genes using unphased and flanking single nucleotide
polymorphisms.
Li SS, Wang H, Smith A, Zhang B, Zhang XC, Schoch G, Geraghty D, Hansen JA,
Zhao LP.
Source
Division of Public Health Sciences, Fred Hutchinson Cancer Research Center,
Seatt... 阅读全帖 |
|
c********n
发帖数: 67 | 25 In vivo real-time visualization of leukocytes and intracellular hydrogen
peroxide levels during a zebrafish acute inflammation assay.
PMID:22341223
h***[email protected]
Thanks very much :) |
|
|
|
|
|
l**********1
发帖数: 5204 | 30 同济医学院科研要赶超复旦和交大了哈 at least Stem Cell parts
发信人: amedio (Boasting Father), 信区: Harvard_Medical_School
标 题: Re: 同济大学生物信息学海外团队招聘启事 (转载)
发信站: BBS 未名空间站 (Sat Nov 7 08:38:57 2009, 美东)
想告诉大家形势严峻，要回去趁早
team
RE
同济大学生物信息学海外团队招聘启事 (转载)
[俱乐部:Harvard_Medical_School][首篇作者：amedio] , 2009年11月06日06:28:26
[分页:1 ]
发信人: amedio (Boasting Father), 信区: Harvard_Medical_School
标 题: 同济大学生物信息学海外团队招聘启事 (转载)
发信站: BBS 未名空间站 (Fri Nov 6 06:28:26 2009, 美东)
【 以下文字转载自 Biology 讨论区 】
发信人: biowilliam (magic), 信区: Biology
标 题: ... 阅读全帖 |
|
f*********e
发帖数: 24 | 31 A microRNA as a translational repressor of APETALA2 in Arabidopsis flower
development.
Chen X.
Science. 2004 Mar 26;303(5666):2022-5. Epub 2003 Jul 31.
PMID:
12893888
[PubMed - indexed for MEDLINE] |
|
|
|
|
s**u
发帖数: 2429 | 35 Mechanisms for osteogenic differentiation of human mesenchymal stem cells
induced by fluid shear stress
PMID: 20309603
my email: e********[email protected] |
|
a********k
发帖数: 2273 | 36 还是老大的得意门生，只能说杨老先生不帮弟子出头。
第二篇Nature,PMID: 22678291 |
|
H*Q
发帖数: 725 | 37 will send you 2 baozi as my appreciation
Expert Opin Investig Drugs. 2012 May 23. [Epub ahead of print]
Sorafenib in locally advanced or metastatic breast cancer.
Gradishar WJ.
PMID: 22616580
email, h********[email protected]
thanks a lot. |
|
G*******s
发帖数: 92 | 38 Delivery of brain-derived neurotrophic factor via nose-to-brain pathway.
Vaka SR, Murthy SN, Balaji A, Repka MA.
Pharm Res. 2012 Feb;29(2):441-7. Epub 2011 Aug 31.
PMID: 21879386 [PubMed - indexed for MEDLINE]
Thanks!
n***********[email protected] |
|
j*****9
发帖数: 716 | 39 一个包子致谢
Serum DKK1 as a protein biomarker for the diagnosis of hepatocellular
carcinoma: a large-scale, multicentre study.
谢谢！
j*****[email protected] |
|
|
|
l********n
发帖数: 260 | 42 Hedrich K, Marder K, Harris J, Kann M, Lynch T, Meija-Santana H, Pramstaller
PP, Schwinger E, Bressman SB, Fahn S, Klein C.
Evaluation of 50 probands with early-onset Parkinson's disease for Parkin
mutations.
Neurology. 2002 Apr 23;58(8):1239-46. PubMed PMID: 11971093. |
|
b****r
发帖数: 17995 | 43 只要有维甲酸这样的例子，你就不能说小分子一定不如放疗化疗给力
类似的，易瑞沙也有证据比化疗更给力
Jackman DM, Miller VA, Cioffredi LA, Yeap BY, Jänne PA, Riely GJ, Ruiz
MG, Giaccone G, Sequist LV, Johnson BE (August 2009). "Impact of epidermal
growth factor receptor and KRAS mutations on clinical outcomes in previously
untreated non-small cell lung cancer patients: results of an online tumor
registry of clinical trials". Clin. Cancer Res. 15 (16): 5267–73. DOI:10.
1158/1078-0432.CCR-09-0888. PMID 19671843.
关键是这些肿瘤多半不是单个致癌突变引起，只抑制一条通路自然很难有... 阅读全帖 |
|
l**********1
发帖数: 5204 | 44 LZ noted this one:
http://www.ncbi.nlm.nih.gov/pubmed/16452195
full text:
//cancerres.aacrjournals.org/content/66/3/1401.abstract
so if
Ji and Ju really half and half that is no problem
but if Ji>55% and Ju <45%
and Ju likes
AP/PI second round tenure tracking needed?
Zhang J*, Zhuang J*, Willers H, Chung J, van Gent DC, Hallahan DE, Powell
SN and Xia F. Chk2-Mediated Phosphorylation of BRCA1 Regulates the Fidelity
of Non-homologous End-joining. Cancer Research, 66(3):1401-8 2006. (*
Cont... 阅读全帖 |
|
d****d
发帖数: 214 | 45 在本科生期间，发了一篇Science三作，Cell一作。老爸也身居高位。这样的人真是前
途不可限量啊。
http://krieger.jhu.edu/magazine/sp10/i10.html
1.
Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1.
Dang EV, Barbi J, Yang HY, Jinasena D, Yu H, Zheng Y, Bordman Z, Fu J, Kim Y
, Yen HR, Luo W, Zeller K, Shimoda L, Topalian SL, Semenza GL, Dang CV,
Pardoll DM, Pan F.
Cell. 2011 Sep 2;146(5):772-84. Epub 2011 Aug 25.
PMID: 21871655 [PubMed - indexed for MEDLINE]
Related citations Item in clipboard
2.
Eos mediates Foxp3-dependent gen... 阅读全帖 |
|
l**********1
发帖数: 5204 | 46 韦氏拼音
Chiu, Wah 趙華
香港出来的
Alvin Romansky Professor of Biochemistry, National Center for
Macromolecular Imaging, Baylor College of Medicine, Houston
//www.bcm.edu/biochem/?PMID=3715
http://www.mitbbs.ca/article_t1/Biology/31665667_0_4.html
or
【Southern Wanwan 訊】在結構生物學蓬勃發展的大趨勢下，台灣已有數個單位設置冷
凍電子顯微鏡核心設施。為能結合臨床與基礎的研究成果以推展結構生物學為基礎的臨
床診斷與治療科技，國立成功大學口腔醫學研究所特別邀請結構生物學家及冷凍電子顯
微鏡專家趙華院士訪台，並在成大演講「Chaperonin-based therapeutics
development for Huntington Disease」，透過演說、論壇與實地訪查促進雙方學術交
流。
//news.secr.ncku.edu.tw/fil... 阅读全帖 |
|
g***j
发帖数: 40861 | 47 Mathusa EC, Chen Y, Enache E, Hontz L. Non-O157 Shiga toxin-producing
Escherichia coli in foods. J Food Prot. 2010 Sep;73(9):1721-36. Review.
PubMed
PMID: 20828483.
s*****[email protected]
谢谢 |
|
C********4
发帖数: 308 | 48 假如下面的文章都是同一个人发表的。
请问在这个领域算是上等，还是中等，还是比较差的？
＝＝＝＝＝＝＝＝
1.
Metallic gold slows disease progression, reduces cell death and induces
astrogliosis while simultaneously increasing stem cell responses in an EAE
rat model of multiple sclerosis.
Pedersen DS, Fredericia PM, Pedersen MO, Stoltenberg M, Penkowa M, Danscher
G, Rungby J, Larsen A.
Histochem Cell Biol. 2012 Jul 22. [Epub ahead of print]
2.
Metallic silver fragments cause massive tissue loss in the mouse brain.
Locht LJ, Pedersen MØ, Markhol... 阅读全帖 |
|
J********n
发帖数: 534 | 49 Non-ATP competitive protein kinase inhibitors.
Garuti L, Roberti M, Bottegoni G.
Curr Med Chem. 2010;17(25):2804-21. Review.
PMID:20586715[PubMed - indexed for MEDLINE] |
|
|
